Domperidone

Level 3: This medication poses a specific safety risk that is likely to be harmful, it should not be taken.

Domperidone is a peripherally selective dopamine receptor antagonist used outside the United States as an anti-emetic and to boost breast milk production in breastfeeding women (both cis and trans). This medication achieves its effects through high blood prolactin levels. This medication has no evidence of its use in gender-affirming care and has significant risks (see "Safety and Effects").

Dosing and Monitoring

Due to having no official use in gender-affirming care, there is no basis for dosing recommendations. Hyperprolactinemia must be monitored with this medication (Madhusoodanan Subramoniam, 2010) (for more information see "Safety and Effects").

Safety and Effects

Domperidone and Hyperprolactinemia

The method of action for domperidone is hyperprolactinemia; it is something the medication directly causes (Madhusoodanan Subramoniam, 2010). Hyperprolactinemia can cause several problems including cardiovascular risk, it also has little to no benefit on gender-affirming care (Haring Robin, 2014)](https://www.doi.org/10.1093/eurheartj/ehs233).

Domperidone and Cardiovascular Problems

Domperidone by itself shows a significant risk of heart arrhythmia a risk that should not be taken lightly by anyone (Ou Linda, 2021). It is unknown if these cardiovascular problems are related to hyperprolactinemia or if they are a problem caused by domperidone itself, thus monitoring for hyperprolactinemia does not completely mitigate this risk.

Seller Product Price Single $/10mg Bulk $/10mg Stock Notes
Japan Health Center (Bio-Japan) Domperidone 10mg x 100 $25.00 $0.25 $0.25 No
Bulgarian Online Pharmacy Domperidone 10mg x 30 £14.00 $0.47 $0.47 Unknown
Pilloid Domperidone Teva 10mg x 30 $14.94 $0.50 $0.50 Unknown
Inhouse Pharmacy Domperidone Viatris 10mg x 100 $32.00 $0.32 $0.32 Unknown
Pharmacy-House Domstal 10mg x 30 $15.60 $0.52 $0.52 Yes
Inhouse Pharmacy Domton 10mg x 100 $32.00 $0.32 $0.32 Unknown
HealthyAreaStore Molax-M 10mg x 100 $26.00 $0.26 $0.26 Unknown
Pilloid Motilak 10mg x 30 $24.56 $0.82 $0.82 Unknown
Pharmacy-House Motilak 10mg x 30 $13.92 $0.46 $0.46 Yes
Inhouse Pharmacy Motilium 10mg x 100 $48.00 $0.48 $0.48 Unknown
RxAisle Motilium 10mg x 21 $29.00 $1.38 $1.16 Unknown
Inhouse Pharmacy Motilium 10mg x 210 $59.00 $0.28 $0.28 Unknown
Medicina Mexico Motilium 10mg x 30 $31.00 $1.03 $1.03 Unknown
Medicina Mexico Motilium 10mg x 30 $32.00 $1.07 $1.07 Unknown
Pilloid Motilium 10mg x 30 $33.44 $1.11 $1.11 Unknown
Pharmacy-House Motilium 10mg x 30 $29.19 $0.97 $0.88 Yes
Pharmacy-House Motilium Express 10mg x 30 $30.95 $1.03 $1.02 Yes
HealthyAreaStore Motilium-M 10mg x 30 $23.00 $0.77 $0.77 Unknown
DashPCT Vomistop 10mg x 10 $4.70 $0.47 $0.47 Yes
Aipctshop Vomistop 10mg x 10 $1.25 $0.12 $0.12 Unknown
AllDayChemist Vomistop 10mg x 30 $8.00 $0.27 $0.27 Yes
ReliableRx Pharmacy Vomistop 10mg x 30 $4.86 $0.16 $0.16 Yes
Inhouse Pharmacy Vomistop 10mg x 500 $77.00 $0.15 $0.15 Unknown
Aipctshop Vomistop 10mg x 500 $58.42 $0.12 $0.12 Unknown
Otokonoko Pharmaceuticals Domperidone 10mg x 100 $50.00 $0.50 $0.50 Yes This seller is currently suffering delays
Pilloid Passagex 10mg x 10 $14.94 $1.49 $1.49 Unknown Chewable Pills.
Pilloid Passagex 10mg x 30 $16.06 $0.54 $0.54 Unknown Chewable Pills.
Inhouse Pharmacy Vomistop 10mg x 200 $52.00 $0.26 $0.26 Unknown Dispersible Tablets.