Estradiol Pills

Level 1a: This medication has significant evidence for its use in transition and no major specific side effects

Estradiol (typically E2 but sometimes Estradiol Valerate) in oral form. Prescribed in many places for trans-feminine people for daily use to increase estradiol levels.

Dosing and Monitoring

Dosing of 2mg to 8mg a day is typical (NH Daily Med)](), however it should be noted that pills typically are more expensive and more difficult to manage than injections. Estradiol pills directly affect estradiol levels in the blood so adjusting in 1-2mg steps based on blood estradiol levels is ideal (150-250 pg/ml). Due to the short half-life of oral estradiol, it may be ideal to split your dose and take it two times a day, twelve hours apart. Monotherapy with pills is rather difficult requiring doses which can be risky, you are better off taking oral estradiol with an anti-androgen.

Safety and Effects

Oral Estradiol by itself has an extremely good safety profile, however, due to its poor bio-availability making it require an anti-androgen (not monotherapy) it is a less safe option compared to injections.

Oral Estradiol and Blood Clots

Oral estradiol does carry an increased risk of blood clots compared to other forms of estradiol, if you smoke or have habits that already increase blood clot risk this may be a factor to consider. Other forms of estradiol do have an increased risk of blood clots however it is not as significant. (Aly 2020).

Seller Product Price Single $/mg Bulk $/mg Stock Notes
Inhouse Pharmacy Estova (EV) 2mg x 84 $55.00 $0.33 $0.33 Unknown
DashPCT Estrabet (EH) 2mg x 28 $12.00 $0.21 $0.21 Yes
Inhouse Pharmacy Estradiol (17β) 2mg x 100 $72.00 $0.36 $0.36 Unknown
Aipctshop Estraheal (EV) 2mg x 28 $12.96 $0.23 $0.23 Unknown
DashPCT Estraheal (EV) 2mg x 28 $4.00 $0.07 $0.07 Yes
Inhouse Pharmacy Estrofem (EH) 1mg x 28 $49.00 $1.75 $1.75 Unknown
United Pharmacies (NL) Estrofem (EH) 1mg x 28 €15.95 $0.57 $0.52 No
United Pharmacies (UK) Estrofem (EH) 1mg x 28 £20.73 $0.74 $0.68 No
Inhouse Pharmacy Estrofem (EH) 2mg x 28 $35.00 $0.62 $0.62 Unknown
Inhouse Pharmacy Estrofem (EH) 2mg x 28 $42.00 $0.75 $0.75 Unknown
HealthyAreaStore Estrofem (EH) 2mg x 28 $29.00 $0.52 $0.52 Unknown
Amazing4Health Estrofem (EH) 2mg x 28 $24.99 $0.45 $0.45 Unknown
Silhouette Beauty Estrofem (EH) 2mg x 28 €19.50 $0.35 $0.35 Unknown
United Pharmacies (US) Estrofem (EH) 2mg x 28 $30.26 $0.54 $0.49 Yes
Favskinhouse Estrofem (EH) 2mg x 28 $18.70 $0.33 $0.33 Unknown
4NRX Pharmacy Estrofem (EH) 2mg x 28 £24.39 £0.44 £0.44 No
United Pharmacies (UK) Estrofem (EH) 2mg x 28 £24.88 $0.44 $0.40 Yes
RxAisle Estrofem (EH) 2mg x 28 $39.00 $0.70 $0.58 Unknown
United Pharmacies (NL) Estrofem (EH) 2mg x 28 €27.40 $0.49 $0.44 No
Bulgarian Online Pharmacy Estrofem (EH) 2mg x 28 £30.00 $0.54 $0.54 Unknown
Bulgarian Online Pharmacy Progydol (EV) 2mg x 28 £30.00 $0.54 $0.54 Unknown
PharmaOnline.TV Progynova (EV) 1mg x 20 39.90 $1.99 $1.99 Unknown
Aipctshop Progynova (EV) 1mg x 28 $14.35 $0.51 $0.51 Unknown
United Pharmacies (UK) Progynova (EV) 1mg x 28 £9.10 $0.33 $0.30 Yes
ReliableRx Pharmacy Progynova (EV) 1mg x 28 $10.00 $0.36 $0.36 Yes
AllDayChemist Progynova (EV) 1mg x 28 $11.00 $0.39 $0.39 Yes
United Pharmacies (UK) Progynova (EV) 1mg x 84 £19.73 $0.23 $0.22 143 days ago
Inhouse Pharmacy Progynova (EV) 1mg x 84 $50.00 $0.60 $0.60 Unknown
Pilloid Progynova (EV) 2mg x 21 $95.81 $2.28 $2.28 Unknown
Pharmacy-House Progynova (EV) 2mg x 21 $85.37 $2.03 $2.00 Yes
Medicina Mexico Progynova (EV) 2mg x 21 $41.00 $0.98 $0.98 Unknown
United Pharmacies (UK) Progynova (EV) 2mg x 28 £16.43 $0.29 $0.26 Yes
AllDayChemist Progynova (EV) 2mg x 28 $15.00 $0.27 $0.27 Yes
DashPCT Progynova (EV) 2mg x 28 $15.00 $0.27 $0.27 Yes
ReliableRx Pharmacy Progynova (EV) 2mg x 28 $11.04 $0.20 $0.20 Yes
Favskinhouse Progynova (EV) 2mg x 28 $12.00 $0.21 $0.21 Unknown
Aipctshop Progynova (EV) 2mg x 28 $23.58 $0.42 $0.42 Unknown
United Pharmacies (UK) Progynova (EV) 2mg x 84 £28.74 $0.17 $0.16 No
Amazing4Health Progynova (EV) 2mg x 84 $39.99 $0.24 $0.24 Unknown
Inhouse Pharmacy Progynova (EV) 2mg x 84 $52.00 $0.31 $0.31 Unknown
United Pharmacies (US) Progynova (EV) 2mg x 84 $34.96 $0.21 $0.19 No
4NRX Pharmacy Progynova (EV) 2mg x 84 £28.17 £0.17 £0.17 No
HealthyAreaStore Progynova (EV) 2mg x 84 $37.00 $0.22 $0.22 Unknown
Otokonoko Pharmaceuticals Estradiol (17β) 4mg x 100 $95.00 $0.24 $0.24 143 days ago This seller is currently suffering delays
TeaHRT Sublingual Estradiol (17β) Oil Dropper 600mg/30ml $100.00 $0.17 $0.13 143 days ago Oil Dropper, contains the equivalent of 300 2mg Estradiol (17β) tablets.